Development of bioactive polyurethaneureas to support endothelialization

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dc.contributor.advisorWest, Jennifer L.
dc.creatorJun, Ho-Wook
dc.date.accessioned2009-06-04T08:15:59Z
dc.date.available2009-06-04T08:15:59Z
dc.date.issued2004
dc.description.abstractVascular diseases are responsible for the majority of deaths in the United States. Synthetic materials have been developed for blood vessel substitutes but not suitable for small diameter vascular applications such as coronary artery bypass grafting (CABG). Polyurethaneureas (PUU) have been widely used for biomedical applications due to their excellent mechanical properties and relatively good biocompatibility. However, like other synthetic materials, they are generally thrombogenic on exposure to blood. Endothelialization of synthetic grafts is a good strategy to improve graft patency. However, the graft patency is dependent on retention of endothelial cells on exposure to physiological shear stress. In this study, we developed bioactive polyurethaneureas to support endothelialization. First, we have demonstrated that endothelial cell behaviors could be altered by the surface YIGSR peptide concentrations. Bioactive polyurethanureas (PUUYIGSR) have been developed by incorporating YIGSR peptide sequences into polymer main chain, and improved endothelialization has been observed on the surface. In addition, PEG- and YIGSR-modified polyurethaneureas (PUUYIGSR-PEG) have been developed, and enhanced endothelialization and improved thromboresistance have been obtained simultaneously. Our bulk modification strategy allowed us to fabricate microporous scaffolds without interfering bioactivity of incorporated peptide sequences. Microporous scaffolds have been also used as a carrier of vascular endothelial growth factor (VEGF). The synergistic effects of peptide sequences, microporous structure, and incorporated VEGF on endothelialization have been observed. Additionally, nitric oxide (NO) releasing polyurethanes (PUBD-NO) have been developed by incorporating NO donor into the polymer main chain. NO was successfully released from the PUBD-NO in controlled manner and reduced platelet adhesion and smooth muscle cell proliferation but improved endothelialization proliferation.
dc.format.extent177 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS BIOENG. 2004 JUN
dc.identifier.citationJun, Ho-Wook. "Development of bioactive polyurethaneureas to support endothelialization." (2004) Diss., Rice University. <a href="https://hdl.handle.net/1911/18652">https://hdl.handle.net/1911/18652</a>.
dc.identifier.urihttps://hdl.handle.net/1911/18652
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectBiomedical engineering
dc.subjectHealth sciences
dc.subjectMedicine
dc.subjectSurgery
dc.titleDevelopment of bioactive polyurethaneureas to support endothelialization
dc.typeThesis
dc.type.materialText
thesis.degree.departmentBioengineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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