Synthetic studies toward the total synthesis of (+)-anthramycin total syntheses of (+)-neothramycins A and B

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dc.contributor.advisorFukuyama, Tohru
dc.creatorLin, Shao-Cheng
dc.date.accessioned2009-06-03T23:57:56Z
dc.date.available2009-06-03T23:57:56Z
dc.date.issued1990
dc.description.abstractThrough the serendipitous discovery of a palladium catalyzed conversion of ethylthiol esters to their corresponding aldehydes, the pyrrolo (1,4) benzodiazepine systems found in (+)-anthramycin 1a* and (+)-neothramycins A 2a and B 2b have been constructed from the diethylthiol esters 3 and 4 respectively. A key intermediate 5 for the total synthesis of (+)-anthramycin and a facile route to (+)-neothramycins A and B are thus provided. ftn*Please refer to dissertation for diagrams.
dc.format.extent190 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoThesis Chem. 1990 Lin
dc.identifier.citationLin, Shao-Cheng. "Synthetic studies toward the total synthesis of (+)-anthramycin total syntheses of (+)-neothramycins A and B." (1990) Diss., Rice University. <a href="https://hdl.handle.net/1911/16364">https://hdl.handle.net/1911/16364</a>.
dc.identifier.digitalLinSen_US
dc.identifier.urihttps://hdl.handle.net/1911/16364
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectOrganic chemistry
dc.subjectPharmaceutical chemistry
dc.titleSynthetic studies toward the total synthesis of (+)-anthramycin total syntheses of (+)-neothramycins A and B
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemistry
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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