Development of Hyperspectral Imagers for Snapshot Optical Coherence Tomography

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dc.contributor.advisorTkaczyk, Tomasz S.
dc.contributor.committeeMemberRichards-Kortum, Rebecca Rae
dc.contributor.committeeMemberBaraniuk, Richard G.
dc.contributor.committeeMemberPierce, Mark C
dc.creatorNguyen, Thuc-Uyen
dc.date.accessioned2014-10-06T21:44:50Z
dc.date.available2014-11-01T05:10:03Z
dc.date.created2014-05
dc.date.issued2014-04-25
dc.date.submittedMay 2014
dc.date.updated2014-10-06T21:44:50Z
dc.description.abstractOptical Coherence Tomography (OCT) is an established interferometry-based technique for volumetric tissue imaging with micrometer resolution, best known in many medical applications such as ophthalmologic imaging and endoscopy. Several clinically recognized examples include retinal imaging to detect glaucoma and age-related macular degeneration (AMD) or cardiovascular imaging when employed with a catheter. Scanning mechanism presenting in all current OCT technology requires moving parts, often limiting the system’s compactness, compromising light throughput and risking unwanted movement. Snapshot imaging thus allows fast and high-throughput acquisition while minimizing motion artifacts caused by instrumental vibration or samples’ transient nature. This thesis presents novel work contributing to the development of a snapshot 3-Dimensional OCT (3D-OCT) system. With theoretical and experimental evaluations, different hyperspectral imaging designs were surveyed to provide enhancements such as high throughput, dense spectral sampling, high sensitivity toward the appropriate spectrum and spatial-spectral tunability. A proof-of-concept snapshot 3D-OCT system is introduced to simultaneously collect signals of a volumetric datacube, enabling cellular visualization of scattering biological samples. This system affords diffraction-limited performance with reduced motion and requires minimal computational time.
dc.embargo.terms2014-11-01
dc.format.mimetypeapplication/pdf
dc.identifier.citationNguyen, Thuc-Uyen. "Development of Hyperspectral Imagers for Snapshot Optical Coherence Tomography." (2014) Diss., Rice University. <a href="https://hdl.handle.net/1911/77422">https://hdl.handle.net/1911/77422</a>.
dc.identifier.urihttps://hdl.handle.net/1911/77422
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectBiomedical optics
dc.subjectOptical coherence tomography
dc.subjectSnapshot optical coherence tomography
dc.subjectImage mapping spectrometry
dc.subjectHyperspectral imaging
dc.titleDevelopment of Hyperspectral Imagers for Snapshot Optical Coherence Tomography
dc.typeThesis
dc.type.materialText
thesis.degree.departmentBioengineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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