Development of Hyperspectral Imagers for Snapshot Optical Coherence Tomography

Simple item page
dc.contributor.advisorTkaczyk, Tomasz S.en_US
dc.contributor.committeeMemberRichards-Kortum, Rebecca Raeen_US
dc.contributor.committeeMemberBaraniuk, Richard G.en_US
dc.contributor.committeeMemberPierce, Mark Cen_US
dc.creatorNguyen, Thuc-Uyenen_US
dc.date.accessioned2014-10-06T21:44:50Zen_US
dc.date.available2014-11-01T05:10:03Zen_US
dc.date.created2014-05en_US
dc.date.issued2014-04-25en_US
dc.date.submittedMay 2014en_US
dc.date.updated2014-10-06T21:44:50Zen_US
dc.description.abstractOptical Coherence Tomography (OCT) is an established interferometry-based technique for volumetric tissue imaging with micrometer resolution, best known in many medical applications such as ophthalmologic imaging and endoscopy. Several clinically recognized examples include retinal imaging to detect glaucoma and age-related macular degeneration (AMD) or cardiovascular imaging when employed with a catheter. Scanning mechanism presenting in all current OCT technology requires moving parts, often limiting the system’s compactness, compromising light throughput and risking unwanted movement. Snapshot imaging thus allows fast and high-throughput acquisition while minimizing motion artifacts caused by instrumental vibration or samples’ transient nature. This thesis presents novel work contributing to the development of a snapshot 3-Dimensional OCT (3D-OCT) system. With theoretical and experimental evaluations, different hyperspectral imaging designs were surveyed to provide enhancements such as high throughput, dense spectral sampling, high sensitivity toward the appropriate spectrum and spatial-spectral tunability. A proof-of-concept snapshot 3D-OCT system is introduced to simultaneously collect signals of a volumetric datacube, enabling cellular visualization of scattering biological samples. This system affords diffraction-limited performance with reduced motion and requires minimal computational time.en_US
dc.embargo.terms2014-11-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationNguyen, Thuc-Uyen. "Development of Hyperspectral Imagers for Snapshot Optical Coherence Tomography." (2014) Diss., Rice University. <a href="https://hdl.handle.net/1911/77422">https://hdl.handle.net/1911/77422</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/77422en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBiomedical opticsen_US
dc.subjectOptical coherence tomographyen_US
dc.subjectSnapshot optical coherence tomographyen_US
dc.subjectImage mapping spectrometryen_US
dc.subjectHyperspectral imagingen_US
dc.titleDevelopment of Hyperspectral Imagers for Snapshot Optical Coherence Tomographyen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
NGUYEN-DOCUMENT-2014.pdf
Size:
3.34 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
LICENSE.txt
Size:
2.61 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.85 KB
Format:
Plain Text
Description:
Download
Collections
Rice University Theses and Dissertations