The origin of microsatellites and their application to the study of social evolution in the cellular slime mold, Dictyostelium discoideum

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dc.contributor.advisorStrassmann, Joan E.en_US
dc.contributor.advisorQueller, David C.en_US
dc.creatorZhu, Yongen_US
dc.date.accessioned2009-06-04T08:19:06Zen_US
dc.date.available2009-06-04T08:19:06Zen_US
dc.date.issued2000en_US
dc.description.abstractData from the Human Gene Mutation Database were used to contrast the alternative hypotheses that microsatellites arise through insertions or through substitutions. The results showed that a high percentage of small insertions created novel microsatellite repeats through the duplication of the adjacent sequences. However substitutions were still the dominant source of new microsatellites since they are so much more common than insertions. Although insertions contributed a minority of new repeat loci, their relative importance increased rapidly with repeat motif sizes. Microsatellite techniques were then applied to examine genetic conflicts in the cellular slime mold, Dictyostelium discoideum. Microsatellite genotyping showed that genetically distinct clones generally formed multicellular fruiting structures together in the mixing experiments. More interestingly, some clones were found to preferentially become reproductive spores instead of non-reproductive altruistic stalk cells. These conflicts of genetic interest make D. discoideum a potential excellent model system for social evolution.en_US
dc.format.extent62 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS ECOL. 2000 ZHUen_US
dc.identifier.citationZhu, Yong. "The origin of microsatellites and their application to the study of social evolution in the cellular slime mold, Dictyostelium discoideum." (2000) Diss., Rice University. <a href="https://hdl.handle.net/1911/19576">https://hdl.handle.net/1911/19576</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/19576en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectMolecular biologyen_US
dc.subjectGeneticsen_US
dc.subjectCell biologyen_US
dc.titleThe origin of microsatellites and their application to the study of social evolution in the cellular slime mold, Dictyostelium discoideumen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentEcology and Evolutionary Biologyen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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