Temporal effects of cell adhesion on the mechanical characteristics of the single chondrocyte

Simple item page
dc.contributor.advisorAthanasiou, Kyriacos A.en_US
dc.creatorHuang, Weien_US
dc.date.accessioned2009-06-04T08:28:12Zen_US
dc.date.available2009-06-04T08:28:12Zen_US
dc.date.issued2001en_US
dc.description.abstractCell adhesion to material surfaces is a fundamental phenomenon in tissue response to implanted devices, and an important consideration in tissue engineering. The first objective of this study was to measure the mechanical adhesiveness characteristics of rabbit articular chondrocytes as a function of seeding time to provide further understanding of the cell adhesion process. The second objective was to quantify the tether formation force and tether stiffness as a function of seeding time. With increasing time of seeding up to 6 hours, chondrocytes exhibited increasing mechanical adhesiveness, tether formation force and tether stiffness, as measured using the cytodetacher and optical tweezers system. Concomitantly, cell contact area and cell height, as measured using inverted microscope and confocal imaging, were found to increase and decrease respectively.en_US
dc.format.extent44 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS BIOENG. 2002 HUANGen_US
dc.identifier.citationHuang, Wei. "Temporal effects of cell adhesion on the mechanical characteristics of the single chondrocyte." (2001) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17511">https://hdl.handle.net/1911/17511</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/17511en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCell biologyen_US
dc.titleTemporal effects of cell adhesion on the mechanical characteristics of the single chondrocyteen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1408670.PDF
Size:
996.66 KB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Theses and Dissertations