Gas chromatography and gateway sensors for on-line state estimation of complex fermentations (butanol/acetone fermentations)

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dc.contributor.advisorPapoutsakis, E. Terryen_US
dc.contributor.committeeMemberRudolph, Frederick B.en_US
dc.contributor.committeeMemberMcIntire, Larry V.en_US
dc.creatorMcLaughlin, Joseph K.en_US
dc.date.accessioned2018-12-18T21:16:20Zen_US
dc.date.available2018-12-18T21:16:20Zen_US
dc.date.issued1984en_US
dc.description.abstractA bench-scale system for monitoring butanol/acetone fermentations was designed to demonstrate the use of on-line gas chromatography (GC) and the applicability of an "advanced" fermentation equation. Ultrafiltration was used to obtain sterilely a cell-free sample from a controlled fermentor for on-line GC analysis of ethanol, acetone, acetate, butanol, acetoin, and butyrate. The fermentor effluent gas was also analyzed by on-line GC for nitrogen, carbon monoxide, and carbon dioxide. Analytical data were automatically transmitted to a VAX 11/75 computer, for data archiving and fermentation equation calculations. The system was demonstrated in studies of pH and CO effects on the metabolism of Clostridium acetobutylicum. The on-line analytical systems provided excellent real time data. Also, three potentially useful gateway sensors were developed from the fermentation equation: glucose concentration, NADH2 from FdH2 and excess ATP. These demonstrated the usefulness of the fermentation equation for determination of intracellular and extracellular parameters in transient operation.en_US
dc.format.digitalOriginreformatted digitalen_US
dc.format.extent202 ppen_US
dc.identifier.callnoTHESIS CH.E. 1984 MCLAUGHLINen_US
dc.identifier.citationMcLaughlin, Joseph K.. "Gas chromatography and gateway sensors for on-line state estimation of complex fermentations (butanol/acetone fermentations)." (1984) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/104022">https://hdl.handle.net/1911/104022</a>.en_US
dc.identifier.digitalRICE1648en_US
dc.identifier.urihttps://hdl.handle.net/1911/104022en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.titleGas chromatography and gateway sensors for on-line state estimation of complex fermentations (butanol/acetone fermentations)en_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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