A comparison of three methods used to determine functionally important protein residues

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dc.contributor.advisorKimmel, Marek
dc.creatorSpratt, Heidi Marie
dc.date.accessioned2009-06-04T08:21:03Z
dc.date.available2009-06-04T08:21:03Z
dc.date.issued2003
dc.description.abstractA new method for determining functionally important protein residues is analyzed and compared with two previously existing methods. This thesis presents the analysis of several different protein sequences and shows how the functionally important protein residues compare between the evolutionary trace method, the maximum likelihood method of protein evolution, and the Hidden Markov method of protein evolution. The results are presented graphically as well as structurally since structure information is known about all the protein sequences studied. All three methods produce similar results for most of the proteins and show that the most highly conserved protein residues are detectable by all three methods but that the less conserved important residues may not always be identified by all methods.
dc.format.extent154 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS STAT. 2003 SPRATT
dc.identifier.citationSpratt, Heidi Marie. "A comparison of three methods used to determine functionally important protein residues." (2003) Diss., Rice University. <a href="https://hdl.handle.net/1911/18564">https://hdl.handle.net/1911/18564</a>.
dc.identifier.urihttps://hdl.handle.net/1911/18564
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectMolecular biology
dc.subjectBiostatistics
dc.subjectStatistics
dc.titleA comparison of three methods used to determine functionally important protein residues
dc.typeThesis
dc.type.materialText
thesis.degree.departmentStatistics
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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