A mathematical model of the vagally driven primary pacemaker cell membrane of the SA node of the heart

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dc.contributor.advisorClark, John W.en_US
dc.contributor.committeeMemberGlantz, Raymon M.en_US
dc.contributor.committeeMemberJohnson, Don H.en_US
dc.creatorBristow, David Grahamen_US
dc.date.accessioned2018-12-18T21:22:44Zen_US
dc.date.available2018-12-18T21:22:44Zen_US
dc.date.issued1982en_US
dc.description.abstractThe study of the electrophyslologlcal activity of the SA node of the heart is currently a subject of considerable Interest In the research community. Information regarding the electrical behavior of the SA node Is by no means complete, yet sufficiently detailed Information Is available In the literature to allow the formulation of a reasonably quantitative model of the primary pacemaker cell membrane, and its vagal Innervation. In this study, the well-known McAlIIster-Noble-Tslen model of cardiac Purklnje fiber Is modified to account for the electrical activity of the SA node. To model the effects of vagal activity on the sinus rhythm a muscarinic channel with dynamics as suggested by Purves and Noma et al. has been added to the basic membrane model. The model mimics the published data quite well and Is capable of characterizing the free running behavior of the SA node, as well as Its response to electrotonic and vagal stimulation.en_US
dc.format.digitalOriginreformatted digitalen_US
dc.format.extent188 ppen_US
dc.identifier.callnoTHESIS E.E. 1982 BRISTOWen_US
dc.identifier.citationBristow, David Graham. "A mathematical model of the vagally driven primary pacemaker cell membrane of the SA node of the heart." (1982) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/104417">https://hdl.handle.net/1911/104417</a>.en_US
dc.identifier.digitalRICE2052en_US
dc.identifier.urihttps://hdl.handle.net/1911/104417en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.titleA mathematical model of the vagally driven primary pacemaker cell membrane of the SA node of the hearten_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Artsen_US
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