Assessment of In Vivo Microscopy for Malaria Detection

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dc.contributor.advisorRichards-Kortum, Rebecca Raeen_US
dc.contributor.committeeMemberDrezek, Rebekahen_US
dc.contributor.committeeMemberTkaczyk, Tomaszen_US
dc.creatorBurnett, Jenniferen_US
dc.date.accessioned2015-10-29T20:47:00Zen_US
dc.date.available2015-10-29T20:47:00Zen_US
dc.date.created2014-05en_US
dc.date.issued2014-10-23en_US
dc.date.submittedMay 2014en_US
dc.date.updated2015-10-29T20:48:00Zen_US
dc.description.abstractHalf of the world’s population is at risk for malaria, yet 90% of deaths due to malaria occur in sub-Saharan Africa, with the highest mortality rates occurring in children under 5. Due to this high mortality rate, children with common flu-like symptoms are often treated for malaria presumptively. This overtreatment with anti-malarial drugs can contribute to the emergence of drug resistant species. Commercially available diagnostic tools, such as blood smear microscopy and rapid diagnostic tests, offer greater specificity than presumptive diagnosis, but require the collection of a finger prick blood sample for diagnosis, generating biohazards and requiring consumables. This thesis introduces a new diagnostic concept to detect parasitized blood cells as they circulate in vivo, avoiding the requirement for blood collection. The work presented here investigates two major components of this concept: 1) develop and characterize a needle-free malaria diagnostic system, and 2) evaluate the performance of the system in biological environments of progressively increasing complexity. Results show promising optical signatures from two biomarkers for malaria detection. This work demonstrates the feasibility for imaging circulating blood cells in vivo through a non-invasive technique, warranting future investigations in a small malaria-infected sample population.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationBurnett, Jennifer. "Assessment of In Vivo Microscopy for Malaria Detection." (2014) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/81989">https://hdl.handle.net/1911/81989</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/81989en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectmalaria diagnosticsen_US
dc.subjectin vivo microscopyen_US
dc.subjectglobal health technologiesen_US
dc.titleAssessment of In Vivo Microscopy for Malaria Detectionen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentApplied Physicsen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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