Bayesian semiparametric and flexible models for analyzing biomedical data

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dc.contributor.advisorCox, Dennis D.
dc.creatorLeon Novelo, Luis G.
dc.date.accessioned2011-07-25T02:06:26Z
dc.date.available2011-07-25T02:06:26Z
dc.date.issued2010
dc.description.abstractIn this thesis I develop novel Bayesian inference approaches for some typical data analysis problems as they arise with biomedical data. The common theme is the use of flexible and semi-parametric Bayesian models and computation intensive simulation-based implementations. In chapter 2, I propose a new approach for inference with multivariate ordinal data. The application concerns the assessment of toxicities in a phase III clinical trial. The method generalizes the ordinal probit model. It is based on flexible mixture models. In chapter 3, I develop a semi-parametric Bayesian approach for bio-panning phage display experiments. The nature of the model is a mixed effects model for repeated count measurements of peptides. I develop a non-parametric Bayesian random effects distribution and show how it can be used for the desired inference about organ-specific binding. In chapter 4, I introduce a variation of the product partition model with a non-exchangeable prior structure. The model is applied to estimate the success rates in a phase II clinical of patients with sarcoma. Each patient presents one subtype of the disease and subtypes are grouped by good, intermediate and poor prognosis. The prior model respects the varying prognosis across disease subtypes. Two subtypes with equal prognoses are more likely a priori to have similar success rates than two subtypes with different prognoses.
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS STAT. 2010 LEON NOVELO
dc.identifier.citationLeon Novelo, Luis G.. "Bayesian semiparametric and flexible models for analyzing biomedical data." (2010) Diss., Rice University. <a href="https://hdl.handle.net/1911/62113">https://hdl.handle.net/1911/62113</a>.
dc.identifier.urihttps://hdl.handle.net/1911/62113
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectBiology
dc.subjectBiostatistics
dc.subjectStatistics
dc.subjectBiomedical engineering
dc.titleBayesian semiparametric and flexible models for analyzing biomedical data
dc.typeThesis
dc.type.materialText
thesis.degree.departmentStatistics
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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