Biomedical Nanocrystal Agents: Design, Synthesis, and Applications

dc.contributor.advisorColvin, Vicki L.en_US
dc.contributor.committeeMemberMcDevitt, John T.en_US
dc.contributor.committeeMemberWong, Michael S.en_US
dc.creatorCho, Minjungen_US
dc.date.accessioned2013-09-16T14:57:38Zen_US
dc.date.accessioned2013-09-16T14:57:58Zen_US
dc.date.available2013-09-16T14:57:38Zen_US
dc.date.available2013-09-16T14:57:58Zen_US
dc.date.created2013-05en_US
dc.date.issued2013-09-16en_US
dc.date.submittedMay 2013en_US
dc.date.updated2013-09-16T14:57:58Zen_US
dc.description.abstractIn these days, nanomaterials are applied in a variety of biomedical applications including magnetic resonance imaging (MRI), cell imaging, drug delivery, and cell separation. Most MRI contrast agents affect the longitudinal relaxation time (T1) and transverse relaxation time (T2) of water protons in the tissue and result in increased positive or negative contrast. Here, we report the optimization of r1 (1/T1) or r2 (1/T2) relaxivity dynamics with diameter controlled gadolinium oxide nanocrystals (2~22 nm) and iron based magnetic nanocrystals (4 ~33 nm). The r1 and r2 MR relaxivity values of hydrated nanocrystals were optimized and examined depending on their core diameter, surface coating, and compositions; the high r1 value of gadolinium oxide was 40-60 S-1mM-1, which is 10-15 fold higher than that of commercial Gd (III) chelates (4.3~4.6 S-1mM-1). Moreover, in vitro toxicological studies revealed that polymer coated nanocrystals suspensions had no significant effect on human dermal fibroblast (HDF) cells even at high concentration. Towards multimodal imaging or multifunctional ability, we developed the iron oxide/QDs complexes, which consist of cores of iron oxide that act as nucleation sites for fluorescent QDs. The choice of variable QDs helped to visualize and remove large iron oxide materials in a magnetic separation. Additionally, diluted materials concentrated on the magnet could be fluorescently detected even at very low concentration. The designed MRI or multifunctional nanomaterials will give great and powerful uses in biomedical applications.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationCho, Minjung. "Biomedical Nanocrystal Agents: Design, Synthesis, and Applications." (2013) Diss., Rice University. <a href="https://hdl.handle.net/1911/71938">https://hdl.handle.net/1911/71938</a>.en_US
dc.identifier.slug123456789/ETD-2013-05-490en_US
dc.identifier.urihttps://hdl.handle.net/1911/71938en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectMagnetic resonance imaging (MRI) contrast agentsen_US
dc.subjectMultifunctional magnetic fluorescent complexesen_US
dc.titleBiomedical Nanocrystal Agents: Design, Synthesis, and Applicationsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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