A mechanistic model for the study of the arterial myogenic response

Simple item page
dc.contributor.advisorClark, John W., Jr.en_US
dc.creatorYang, Jinen_US
dc.date.accessioned2009-06-04T06:53:06Zen_US
dc.date.available2009-06-04T06:53:06Zen_US
dc.date.issued2002en_US
dc.description.abstractThis study is concerned with the development of a multiple compartment model of the isolated cerebral artery in rat. The smooth muscle/arterial wall complex is an important component of the circulatory model and serves as a "vasomotor organ", which provides the myogenic mechanism that underlies the phenomenon of the autoregulation of blood flow. We have focused on this myogenic mechanism and have developed a model of the electrophysiological and contractile characteristics of the single smooth muscle cell of the posterior cerebral artery. This cell model is used to interrelate the topics of arterial wall stress, changes in transmembrane potential, intracellular Ca 2+ concentration and contraction. Moreover, the smooth muscle cell model is imbedded in a larger arterial wall model which converts contractile activity into changes in lumen diameter. The complete model consisting of component models of cell, wall, vessel and testing apparatus is used to provide biophysically based explanations of the myogenic mechanisms underlying the autoregulation of cerebral blood flow.en_US
dc.format.extent88 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS E.E. 2002 YANGen_US
dc.identifier.citationYang, Jin. "A mechanistic model for the study of the arterial myogenic response." (2002) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17564">https://hdl.handle.net/1911/17564</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/17564en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBiomedical engineeringen_US
dc.subjectBiophysicsen_US
dc.titleA mechanistic model for the study of the arterial myogenic responseen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1408723.PDF
Size:
2.88 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Theses and Dissertations