A mechanistic model for the study of the arterial myogenic response

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dc.contributor.advisorClark, John W., Jr.
dc.creatorYang, Jin
dc.date.accessioned2009-06-04T06:53:06Z
dc.date.available2009-06-04T06:53:06Z
dc.date.issued2002
dc.description.abstractThis study is concerned with the development of a multiple compartment model of the isolated cerebral artery in rat. The smooth muscle/arterial wall complex is an important component of the circulatory model and serves as a "vasomotor organ", which provides the myogenic mechanism that underlies the phenomenon of the autoregulation of blood flow. We have focused on this myogenic mechanism and have developed a model of the electrophysiological and contractile characteristics of the single smooth muscle cell of the posterior cerebral artery. This cell model is used to interrelate the topics of arterial wall stress, changes in transmembrane potential, intracellular Ca 2+ concentration and contraction. Moreover, the smooth muscle cell model is imbedded in a larger arterial wall model which converts contractile activity into changes in lumen diameter. The complete model consisting of component models of cell, wall, vessel and testing apparatus is used to provide biophysically based explanations of the myogenic mechanisms underlying the autoregulation of cerebral blood flow.
dc.format.extent88 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS E.E. 2002 YANG
dc.identifier.citationYang, Jin. "A mechanistic model for the study of the arterial myogenic response." (2002) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17564">https://hdl.handle.net/1911/17564</a>.
dc.identifier.urihttps://hdl.handle.net/1911/17564
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectBiomedical engineering
dc.subjectBiophysics
dc.titleA mechanistic model for the study of the arterial myogenic response
dc.typeThesis
dc.type.materialText
thesis.degree.departmentElectrical Engineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
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