Development and Characterization of a Novel Class of Self-Assembling dsRNA Cancer Therapeutics

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dc.contributor.advisorDrezek, Rebekahen_US
dc.creatorAsthana, Vishwaratnen_US
dc.date.accessioned2019-05-17T16:00:29Zen_US
dc.date.available2019-08-01T05:01:08Zen_US
dc.date.created2018-08en_US
dc.date.issued2018-08-03en_US
dc.date.submittedAugust 2018en_US
dc.date.updated2019-05-17T16:00:29Zen_US
dc.description.abstractCancer has proven to be an extremely difficult challenge to treat. Several fundamental issues currently underlie cancer treatment including differentiating self from non-self, functional coupling of the recognition and therapeutic components of various therapies, and the propensity of cancerous cells to develop resistance to common treatment modalities via evolutionary pressure. Given these limitations, there is a profound need to develop an all encompassing therapeutic that can uniquely target malignant cells, decouple recognition from treatment, and overcome cancer resistance. We describe herein, a new class of programmable self-assembling dsRNA-based cancer therapeutics that uniquely targets aberrant genetic sequences, and in a functionally decoupled manner, initiates a therapeutic polymerization cascade that induces apoptosis and immune activation. We further show that a DNA protector can be used to selectively seal the therapeutic RNA and induce specific and potent killing of cells containing the target oncogenic sequence, but not wildtype.en_US
dc.embargo.terms2019-08-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationAsthana, Vishwaratn. "Development and Characterization of a Novel Class of Self-Assembling dsRNA Cancer Therapeutics." (2018) Diss., Rice University. <a href="https://hdl.handle.net/1911/105831">https://hdl.handle.net/1911/105831</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/105831en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCanceren_US
dc.subjectdsRNAen_US
dc.titleDevelopment and Characterization of a Novel Class of Self-Assembling dsRNA Cancer Therapeuticsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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