This thesis will discuss the principles, techniques and applications of the Radio Frequency Single Electron Transistor (RF-SET). In the first part, the operating principles of Single Electron Transistors (SETS) in the normal and superconducting states will be introduced. The general techniques of fabricating and calibrating SETs will also be introduced. In the second part, two of our recent experiments are reviewed. One is related to the sensitivity and linearity of superconducting RF-SETs. We found that the RF-SET achieves the best balance of charge sensitivity and linearity in the subgap regime, as opposed to the usual preferred working point in the above-gap regime. The second experiment relates to the real-time counting of single electrons. We demonstrated that the RF-SET can be used as a fast and ultra-sensitive electrometer which can even detect tunneling of a single electron inside a tunable quantum dot (QD) formed in a two dimensional electron gas (2DEG).