Mechanisms of SARS-CoV-2-induced Encephalopathy and Encephalitis in COVID-19 Cases

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dc.citation.journalTitleNeuroscience Insightsen_US
dc.citation.volumeNumber18en_US
dc.contributor.authorVengalil, Aaronen_US
dc.contributor.authorNizamutdinov, Damiren_US
dc.contributor.authorSu, Matthewen_US
dc.contributor.authorHuang, Jason H.en_US
dc.date.accessioned2023-08-07T16:37:50Zen_US
dc.date.available2023-08-07T16:37:50Zen_US
dc.date.issued2023en_US
dc.description.abstractThe SARS-CoV-2 virus caused an unprecedented pandemic around the globe, infecting 36.5 million people and causing the death of over 1 million in the United States of America alone. COVID-19 patients demonstrated respiratory symptoms, cardiovascular complications, and neurologic symptoms, which in most severe cases included encephalopathy and encephalitis. Hypoxia and the uncontrolled proliferation of cytokines are commonly recognized to cause encephalopathy, while the retrograde trans-synaptic spread of the virus is thought to cause encephalitis in SARS-CoV-2-induced pathogenesis. Although recent research revealed some mechanisms explaining the development of neurologic symptoms, it still remains unclear whether interactions between these mechanisms exist. This review focuses on the discussion and analysis of previously reported hypotheses of SARS-CoV-2-induced encephalopathy and encephalitis and looks into possible overlaps between the pathogenesis of both neurological outcomes of the disease. Promising therapeutic approaches to prevent and treat SARS-CoV-2-induced neurological complications are also covered. More studies are needed to further investigate the dominant mechanism of pathogenesis for developing more effective preventative measures in COVID-19 cases with the neurologic presentation.en_US
dc.identifier.citationVengalil, Aaron, Nizamutdinov, Damir, Su, Matthew, et al.. "Mechanisms of SARS-CoV-2-induced Encephalopathy and Encephalitis in COVID-19 Cases." <i>Neuroscience Insights,</i> 18, (2023) Sage: https://doi.org/10.1177/26331055231172522.en_US
dc.identifier.doihttps://doi.org/10.1177/26331055231172522en_US
dc.identifier.urihttps://hdl.handle.net/1911/115050en_US
dc.language.isoengen_US
dc.publisherSageen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial (CC BY-NC) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder. en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.titleMechanisms of SARS-CoV-2-induced Encephalopathy and Encephalitis in COVID-19 Casesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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