Magneto-mechanical Neuromodulation

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dc.contributor.advisorRobinson, Jacob Ten_US
dc.contributor.committeeMemberKemere, Caleben_US
dc.contributor.committeeMemberHafner, Jasonen_US
dc.creatorMurphy, Daniel Ben_US
dc.date.accessioned2016-02-05T14:55:31Zen_US
dc.date.available2016-02-05T14:55:31Zen_US
dc.date.created2015-05en_US
dc.date.issued2015-04-24en_US
dc.date.submittedMay 2015en_US
dc.date.updated2016-02-05T14:55:32Zen_US
dc.description.abstractNoninvasive control of the electrical activity in specific cells in the brain would transform fundamental neuroscience research and the development of therapeutic technologies. Current neural stimulation methods such as electrical or optogenetic stimulation achieve high levels of specificity, but are invasive. Magnetic stimulation is a potentially noninvasive stimulation modality because mammalian tissue is nearly transparent to magnetic fields. In this thesis we investigate a new neural modulation method based on magnetic fields that can potentially achieve similar levels of specificity with much lower invasiveness. Our method will use externally applied, uniform magnetic fields that induce dipole-dipole forces between superparamagnetic iron oxide nanoparticles bound to Piezo1, a mechanically sensitive ion channel. Based on our calculations and early preliminary results, these mechanical forces will be sufficient to open Piezo1, leading to cationic currents, that will alter cell activity. Expression of mutant Piezo1 protein can be targeted to genetically specific populations of cells by means of cell-type specific promoters in transgenic animals. This method is expected to achieve accurate control of genetically specific populations of cells, thereby enabling better research to answer fundamental biological questions and develop novel medical therapies.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationMurphy, Daniel B. "Magneto-mechanical Neuromodulation." (2015) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/88372">https://hdl.handle.net/1911/88372</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/88372en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectmagneto-mechanicalen_US
dc.subjectneuromodulationen_US
dc.subjectmechanotransductionen_US
dc.subjectPiezo1en_US
dc.subjectmagnetogeneticsen_US
dc.titleMagneto-mechanical Neuromodulationen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentApplied Physicsen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.majorApplied Physics/Electrical Engen_US
thesis.degree.nameMaster of Scienceen_US
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