Diversifying selective pressure on influenza B virus hemagglutinin

Simple item page
dc.contributor.advisorMa, Jianpengen_US
dc.creatorShen, Junen_US
dc.date.accessioned2011-07-25T01:38:12Zen_US
dc.date.available2011-07-25T01:38:12Zen_US
dc.date.issued2009en_US
dc.description.abstractInfluenza B virus hemagglutinin (HA) is a major surface glycoprotein with frequent amino-acid substitutions. However, the roles of antibody selection in the amino-acid substitutions of HA were still poorly understood. In order to gain insights into this important issue, an analysis was conducted on a total of 271 HA1 sequences of influenza B virus strains isolated during 1940∼2007. In this analysis, PAML (Phylogenetic Analysis by Maximum Likelihood) package was used to detect the existence of positive selection and to identify positively selected sites on HA1. Strikingly, all the positively selected sites were located in the four major epitopes (120-loop, 150-loop, 160-loop and 190-helix) of HA identified in previous studies, thus supporting a predominant role of antibody selection in HA evolution. Of particular significance is the involvement of the 120-loop in positive selection, which may become increasingly important in future field isolates. Despite the absence of different subtypes, influenza B virus HA continued to evolve into new sublineages, within which the four major epitopes were targeted selectively in positive selection. Thus, any newly emerging strains need to be placed in the context of their evolutionary history in order to understand and predict their epidemic potential.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS PHYS. 2009 SHENen_US
dc.identifier.citationShen, Jun. "Diversifying selective pressure on influenza B virus hemagglutinin." (2009) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/61806">https://hdl.handle.net/1911/61806</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/61806en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBiologyen_US
dc.subjectGeneticsen_US
dc.subjectBiology, Virologyen_US
dc.titleDiversifying selective pressure on influenza B virus hemagglutininen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentPhysicsen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1466841.PDF
Size:
650.49 KB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Theses and Dissertations