Gauss Integral as a structural descriptor of proteins

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dc.contributor.advisorMa, Jianpeng
dc.creatorMei, Yuan
dc.date.accessioned2018-12-03T18:31:53Z
dc.date.available2018-12-03T18:31:53Z
dc.date.issued2008
dc.description.abstractProtein is one of the most important macromolecules in structural biology. Its three-dimensional structure is uniquely determined by its amino-acid sequence. Due to large number of degrees of freedom and enormous diversity, it is important to seek universal geometric measures to describe the overall structure of proteins. Gauss Integral and its related quantities are shown to be capable of describing important features of protein structures on different levels. On the atomic level, the Gauss Integral provides a simple measure to illustrate the orientational relation between different atom groups. It can be viewed as a generalization of the Ramachandran map, and it also reveals several novel relations between backbone atoms. On the other hand, Gauss Integrals can be treated as a set of collective quantities that capture the overall shape of proteins. By comparing the values of Gauss Integrals, different types of proteins can be classified in accordance with the results of manually classified structure database.
dc.format.extent55 pp
dc.identifier.callnoTHESIS PHYS. 2008 MEI
dc.identifier.citationMei, Yuan. "Gauss Integral as a structural descriptor of proteins." (2008) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/103615">https://hdl.handle.net/1911/103615</a>.
dc.identifier.digital304510883
dc.identifier.urihttps://hdl.handle.net/1911/103615
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectBiophysics
dc.subjectBiological sciences
dc.titleGauss Integral as a structural descriptor of proteins
dc.typeThesis
dc.type.materialText
thesis.degree.departmentPhysics
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
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