Receptor mediated adhesion of sickle erythrocytes and damage to IL-1 beta stimulated endothelial cells under flow conditions in vitro
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Enhanced, abnormal adherence of sickle erythrocytes to the endothelium lining blood vessels is hypothesized to contribute to vasoocclusion in sickle cell patients, but the specific molecular mechanisms by which these erythrocyte-endothelial interactions occur have not yet been fully elucidated. Alteration of endothelial function, or frank endothelial damage, may also be involved in the pathogenesis of vascular occlusion. In this thesis, these two different aspects of vascular occlusion, namely adhesion and damage, were studied.
A parallel plate flow chamber and computerized phase contrast microscopy coupled to digital image processing were used to visualize and analyze the adhesion of sickle red cells to 1, 4 and 24 hour IL-1
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Natarajan, Maya. "Receptor mediated adhesion of sickle erythrocytes and damage to IL-1 beta stimulated endothelial cells under flow conditions in vitro." (1996) Diss., Rice University. https://hdl.handle.net/1911/16917.