Functionalized Nanoparticles for Biomedical Applications

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dc.contributor.advisorBillups, W. Edwarden_US
dc.contributor.committeeMemberHauge, Robert H.en_US
dc.contributor.committeeMemberPasquali, Matteoen_US
dc.creatorBryant, Erikaen_US
dc.date.accessioned2013-09-16T14:50:02Zen_US
dc.date.accessioned2013-09-16T14:50:06Zen_US
dc.date.available2013-09-16T14:50:02Zen_US
dc.date.available2013-09-16T14:50:06Zen_US
dc.date.created2013-05en_US
dc.date.issued2013-09-16en_US
dc.date.submittedMay 2013en_US
dc.date.updated2013-09-16T14:50:06Zen_US
dc.description.abstractFunctionalization of nanoparticles often control the extent of their usage. With this in mind, I have explored methods of creating highly functionalized exfoliated graphite, by way of the Billups-Birch reduction, that can be used in the advancement of nanotechnology (i.e. biomedicine). The method explored the use of sodium as the source for the solvated electron. The results of this method produced exfoliated graphite the same size as graphene and with solubility similar to the substrates attached to it. It was further shown that functionalized graphite with a terminal carboxyl group allowed further synthesis to occur via an elimination-addition reaction after the acyl group was transformed into an acid chloride. This reaction makes it possible to create exfoliated graphite that contains any compound of interest as long as it has an oxygen or nitrogen group that is able to react with the acid chloride. Thus, these products have the potential to be used in biomedicine as drug delivery agents.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationBryant, Erika. "Functionalized Nanoparticles for Biomedical Applications." (2013) Diss., Rice University. <a href="https://hdl.handle.net/1911/71926">https://hdl.handle.net/1911/71926</a>.en_US
dc.identifier.slug123456789/ETD-2013-05-556en_US
dc.identifier.urihttps://hdl.handle.net/1911/71926en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectAcid-chlorideen_US
dc.subjectAlkylcarboxylationen_US
dc.subjectAlkylationen_US
dc.subjectBillups-Birchen_US
dc.subjectExfoliated graphiteen_US
dc.subjectGrapheneen_US
dc.subjectNanotechnologyen_US
dc.titleFunctionalized Nanoparticles for Biomedical Applicationsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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