Total synthesis of mitomycins
Abstract
The total synthesis of mitomycins via isomitomycin A is described. Key reactions are a Michael-type coupling reaction between chalcone (94)* and 5-ethylthio-2-trimethylsiloxyfuran, followed by an azido-olefin cyclization. The first route took 30 steps from 2,6-dimethoxytoluene in a overall yield of 6%. The improved second route contains 26 steps with overall yield of 10% from the same staring material. Resolution of an synthetic intermediate resulted in both (+)- and (
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Citation
Yang, Lihu. "Total synthesis of mitomycins." (1990) Diss., Rice University. https://hdl.handle.net/1911/16409.