Cooperative mechanisms in coupled motor proteins transport

Simple item page
dc.contributor.advisorKolomeisky, Anatoly B.en_US
dc.creatorUppulury, Karthiken_US
dc.date.accessioned2013-03-08T00:39:46Zen_US
dc.date.available2013-03-08T00:39:46Zen_US
dc.date.issued2012en_US
dc.description.abstractSubcellular cargos are transported by enzyme molecules called molecular motors by using the chemical energy from hydrolysis of ATP and performing mechanical work in non-equilibrium. Certain motors tread on cytoskeleton structures i.e. microtubules and actin filaments in a linear manner. Due to the polarity of the cytoskeleton structures the motors can accomplish cellular transport along one direction. Cargos often rely upon the collective action of more than one motor to transport them in order to surmount the crowding and visco-elastic effects of the surrounding medium through higher force generation. To understand the mechanism of cargo transport by precisely two kinesin-1 motors a combination of experimental and theoretical approaches were employed. This thesis focuses on understanding the mechanism of transport by considering interactions between closely spaced motors on the microtubules. The main finding of this thesis is that motors under the influence of each other's interaction with microtubules do affect the cargo dynamics.en_US
dc.format.extent33 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS CHEM. 2012 UPPULURYen_US
dc.identifier.citationUppulury, Karthik. "Cooperative mechanisms in coupled motor proteins transport." (2012) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/70479">https://hdl.handle.net/1911/70479</a>.en_US
dc.identifier.digitalUppuluryKen_US
dc.identifier.urihttps://hdl.handle.net/1911/70479en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectPure sciencesen_US
dc.subjectBiological sciencesen_US
dc.subjectCellular biologyen_US
dc.subjectCondensed matter physicsen_US
dc.subjectBiophysicsen_US
dc.titleCooperative mechanisms in coupled motor proteins transporten_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Artsen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
UppuluryK.pdf
Size:
2.33 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Theses and Dissertations