Cooperative mechanisms in coupled motor proteins transport

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dc.contributor.advisorKolomeisky, Anatoly B.
dc.creatorUppulury, Karthik
dc.date.accessioned2013-03-08T00:39:46Z
dc.date.available2013-03-08T00:39:46Z
dc.date.issued2012
dc.description.abstractSubcellular cargos are transported by enzyme molecules called molecular motors by using the chemical energy from hydrolysis of ATP and performing mechanical work in non-equilibrium. Certain motors tread on cytoskeleton structures i.e. microtubules and actin filaments in a linear manner. Due to the polarity of the cytoskeleton structures the motors can accomplish cellular transport along one direction. Cargos often rely upon the collective action of more than one motor to transport them in order to surmount the crowding and visco-elastic effects of the surrounding medium through higher force generation. To understand the mechanism of cargo transport by precisely two kinesin-1 motors a combination of experimental and theoretical approaches were employed. This thesis focuses on understanding the mechanism of transport by considering interactions between closely spaced motors on the microtubules. The main finding of this thesis is that motors under the influence of each other's interaction with microtubules do affect the cargo dynamics.
dc.format.extent33 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS CHEM. 2012 UPPULURY
dc.identifier.citationUppulury, Karthik. "Cooperative mechanisms in coupled motor proteins transport." (2012) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/70479">https://hdl.handle.net/1911/70479</a>.
dc.identifier.digitalUppuluryKen_US
dc.identifier.urihttps://hdl.handle.net/1911/70479
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectPure sciences
dc.subjectBiological sciences
dc.subjectCellular biology
dc.subjectCondensed matter physics
dc.subjectBiophysics
dc.titleCooperative mechanisms in coupled motor proteins transport
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemistry
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Arts
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