Ultrashort Single-walled Carbon Nanotubes: A Platform for Medical Imaging and Therapy

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dc.contributor.advisorWilson, Lon J.en_US
dc.contributor.committeeMemberTour, James Men_US
dc.contributor.committeeMemberWong, Michael Sen_US
dc.contributor.committeeMemberCurley, Steven Aen_US
dc.creatorLaw, Justin Jonathanen_US
dc.date.accessioned2016-01-11T16:56:39Zen_US
dc.date.available2016-01-11T16:56:39Zen_US
dc.date.created2015-05en_US
dc.date.issued2015-04-21en_US
dc.date.submittedMay 2015en_US
dc.date.updated2016-01-11T16:56:39Zen_US
dc.description.abstractUltra-short single-walled carbon nanotubes (US-tubes) have been used to encapsulate various metal ions and small molecules for both diagnostic and therapeutic applications. Of the US-tube derivatives, one of the best characterized is the gadonanotube (GNT). GNTs are remarkable due to their greatly enhanced relaxivity, which is up to 40 times larger than current clinically available gadolinium based contrast. The work in this thesis explores the mechanisms contributing to this phenomenon. This is accomplished by using a series of closely related chelating ligands to explore the role of the coordination environment on the loading, retention, and relaxivity of gadolinium ions within the US-tubes. Further, the chelation system is applied to the positron emitting radioisotope <sup>64</sup>Cu and concurrent loading with gadolinium ions to produce bimodal imaging agents is discussed. In order to assess the viability of US-tubes as a platform for delivering medically relevant molecules, the biocompatibility of the US-tubes is explored. The cellular uptake and subcellular localization of the US-tubes is determined by Raman mapping and differences in US-tube aggregation and cellular response are analyzed. A strategy for enhancing water solubility of US-tube derivatives while retaining encapsulated ions is discussed. Finally, the heating properties of US-tubes in an external radiofrequency field are assessed to determine potential therapeutic applications.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationLaw, Justin Jonathan. "Ultrashort Single-walled Carbon Nanotubes: A Platform for Medical Imaging and Therapy." (2015) Diss., Rice University. <a href="https://hdl.handle.net/1911/87806">https://hdl.handle.net/1911/87806</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/87806en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectCarbon Nanotubesen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectPositron Emission Tomographyen_US
dc.subjectRadiofrequency Heatingen_US
dc.titleUltrashort Single-walled Carbon Nanotubes: A Platform for Medical Imaging and Therapyen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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