Multi-Modal Imaging Techniques for Early Cancer Diagnostics

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dc.contributor.advisorTkaczyk, Tomasz S.en_US
dc.contributor.committeeMemberRichards-Kortum, Rebecca Raeen_US
dc.contributor.committeeMemberMerenyi, Erzsebeten_US
dc.contributor.committeeMemberGillenwater, Ann M.en_US
dc.creatorBedard, Noahen_US
dc.date.accessioned2012-09-06T04:31:49Zen_US
dc.date.accessioned2012-09-06T04:32:23Zen_US
dc.date.available2012-09-06T04:31:49Zen_US
dc.date.available2012-09-06T04:32:23Zen_US
dc.date.created2012-05en_US
dc.date.issued2012-09-05en_US
dc.date.submittedMay 2012en_US
dc.date.updated2012-09-06T04:32:24Zen_US
dc.description.abstractCancer kills more Americans under the age of 75 than any other disease. Although most cancers occur in epithelial surfaces that can be directly visualized, the majority of cases are detected at an advanced stage. Optical imaging and spectroscopy may provide a solution to the need for non-invasive and effective early detection tools. These technologies are capable of examining tissue over a wide range of spatial scales, with widefield macroscopic imaging typically spanning several square-centimeters, and high resolution in vivo microscopy techniques enabling cellular and subcellular features to be visualized. This work presents novel technologies in two important areas of optical imaging: high resolution imaging and widefield imaging. For subcellular imaging applications, new high resolution endomicroscope techniques are presented with improved lateral resolution, larger field-of-view, increased contrast, decreased background signal, and reduced cost compared to existing devices. A new widefield optical technology called multi-modal spectral imaging is also developed. This technique provides real-time in vivo spectral data over a large field-of-view, which is useful for detecting biochemical alterations associated with neoplasia. The described devices are compared to existing technologies, tested using ex vivo tissue specimens, and evaluated for diagnostic potential in a multi-patient oral cancer clinical trial.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationBedard, Noah. "Multi-Modal Imaging Techniques for Early Cancer Diagnostics." (2012) Diss., Rice University. <a href="https://hdl.handle.net/1911/64685">https://hdl.handle.net/1911/64685</a>.en_US
dc.identifier.slug123456789/ETD-2012-05-154en_US
dc.identifier.urihttps://hdl.handle.net/1911/64685en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBiomedical engineeringen_US
dc.subjectBioengineeringen_US
dc.subjectOptical engineeringen_US
dc.subjectOptical diagnosticsen_US
dc.subjectCancer detectionen_US
dc.titleMulti-Modal Imaging Techniques for Early Cancer Diagnosticsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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