A microsatellite-based statistic for inferring patterns of population growth: Sampling properties and hypothesis testing

Simple item page
dc.contributor.advisorKimmel, Marek
dc.creatorKing, J. Patrick
dc.date.accessioned2009-06-04T06:26:15Z
dc.date.available2009-06-04T06:26:15Z
dc.date.issued2000
dc.description.abstractDNA sequences sampled from a genetic locus within a population are related by a genealogy. If there is no recombination within the locus, each pair of sequences is descended from some ancestral sequence, one of which is the most recent common ancestor of the entire sample. Past demography shapes this genealogy since the branch lengths depend on the size history of the population. For this reason, observed distributions of allelic types carry information about the population's demographic history. Because of their abundance and relative ease of typing, microsatellites, or short tandem repeats, represent a useful class of loci for the study of demography. This thesis investigates the properties of the imbalance index beta, a microsatellite-based statistic constructed for demographic inference. Simulated data sets are used to explore the sampling properties of beta and to compare its performance to that of other statistics available in the literature. Tests based on these statistics are applied to samples of microsatellite loci from human populations, and the results are interpreted in light of recent hypotheses concerning the evolution of modern humans.
dc.format.extent119 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS STAT. 2000 KING
dc.identifier.citationKing, J. Patrick. "A microsatellite-based statistic for inferring patterns of population growth: Sampling properties and hypothesis testing." (2000) Diss., Rice University. <a href="https://hdl.handle.net/1911/19523">https://hdl.handle.net/1911/19523</a>.
dc.identifier.urihttps://hdl.handle.net/1911/19523
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectGenetics
dc.subjectStatistics
dc.titleA microsatellite-based statistic for inferring patterns of population growth: Sampling properties and hypothesis testing
dc.typeThesis
dc.type.materialText
thesis.degree.departmentStatistics
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
9969283.PDF
Size:
3.32 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Electronic Theses and Dissertations