Optical characterization and in vivo assessment of charge-assembled capsules containing indocyanine green for laser-mediated diagnosis and therapy

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dc.contributor.advisorAnvari, Bahmanen_US
dc.creatorYaseen, Mohammad Abbasen_US
dc.date.accessioned2009-06-03T19:50:54Zen_US
dc.date.available2009-06-03T19:50:54Zen_US
dc.date.issued2008en_US
dc.description.abstractWe have developed a carrier system to encapsulate Indocyanine Green (ICG) to overcome its limitations for laser-mediated medical applications. Charge-assembled capsules with controllable size and adjustable coatings efficiently encapsulate ICG and effectively stabilize its optical properties. When encapsulated, ICG retains its pronounced light absorption and fluorescence properties in the near infrared spectral range. The capsules' in vivo circulation kinetics and biodistribution can be adjusted by coating the surface with various polymers or nanoparticles. The stability enhancement of ICG's optical properties by encapsulation within our capsule system was investigated using absorbance spectroscopy. The ability of capsules containing ICG to induce photothermolysis was demonstrated in an ex vivo tumorous tissue model. Biodistribution of capsules with different coating material and of different sizes was evaluated in a healthy mouse model. And the circulation kinetics and imaging quality of capsules with different coatings was assessed in mice using in vivo fluorescence imaging. Capsules containing ICG show promise for a variety of laser-mediated medical applications including phothothermal treatment of tumors and vascular lesions as well as fluorescence-based pulmonary imaging.en_US
dc.format.extent141 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS BIOENG. 2008 YASEENen_US
dc.identifier.citationYaseen, Mohammad Abbas. "Optical characterization and in vivo assessment of charge-assembled capsules containing indocyanine green for laser-mediated diagnosis and therapy." (2008) Diss., Rice University. <a href="https://hdl.handle.net/1911/22214">https://hdl.handle.net/1911/22214</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/22214en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBiomedical engineeringen_US
dc.subjectChemical engineeringen_US
dc.titleOptical characterization and in vivo assessment of charge-assembled capsules containing indocyanine green for laser-mediated diagnosis and therapyen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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