Protein adsorption on tailored oligo(ethylene glycol) surfaces

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dc.contributor.advisorLaibinis, Paul E.en_US
dc.creatorGriffin, Vesta Leighen_US
dc.date.accessioned2009-06-04T06:25:45Zen_US
dc.date.available2009-06-04T06:25:45Zen_US
dc.date.issued2006en_US
dc.description.abstractUnwanted protein adsorption is a problem in many areas of biotechnology and medicine where biological samples contact the surface of a material. This thesis has employed self-assembled monolayers (SAMs) of controlled composition to examine the influence that specific chemical interactions have on the protein adsorption characteristics of a surface. Specifically, the effects of surface hydrophilicity and of conformational mobility were examined using a series of mixed SAMs formed on gold, where one component included a terminating oligo(ethylene glycol) (OEG) tail group and the other was a simple unsubstituted n-alkyl chain used to modulate the surface energy of the mixed SAM and the free space available to the OEG tail group. The composition of the surface was easily varied by changing the ratio of alkanethiols in a solution used to form the SAM. The resulting mixed SAMs were characterized by wetting measurements using water, ellipsometry to determine film thickness, and x-ray photoelectron spectroscopy (XPS) to determine composition. (Abstract shortened by UMI.)en_US
dc.format.extent86 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS CH.E. 2006 GRIFFINen_US
dc.identifier.citationGriffin, Vesta Leigh. "Protein adsorption on tailored oligo(ethylene glycol) surfaces." (2006) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17878">https://hdl.handle.net/1911/17878</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/17878en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBiomedical engineeringen_US
dc.subjectChemical engineeringen_US
dc.subjectEngineeringen_US
dc.subjectMaterials scienceen_US
dc.titleProtein adsorption on tailored oligo(ethylene glycol) surfacesen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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