Millimeter-sized battery-free epidural cortical stimulators

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dc.contributor.advisorRobinson, Jacob T.en_US
dc.creatorWoods, Joshuaen_US
dc.date.accessioned2024-01-24T21:46:05Zen_US
dc.date.available2024-01-24T21:46:05Zen_US
dc.date.created2023-12en_US
dc.date.issued2023-10-04en_US
dc.date.submittedDecember 2023en_US
dc.date.updated2024-01-24T21:46:05Zen_US
dc.descriptionEMBARGO NOTE: This item is embargoed until 2024-12-01en_US
dc.description.abstractRefractory neurological and psychiatric disorders are increasingly treated with brain stimulation therapies using implanted neuromodulation devices. Current commercially available stimulation systems, however, are limited by the need for implantable pulse generators and wired power; the complexity of this architecture creates multiple failure points including lead fractures, migration, and infection. Enabling less invasive approaches could increase access to these therapies. Here we demonstrate the first millimeter-sized leadless brain stimulator in large animal and human subjects. This Digitally programmable Over-brain Therapeutic (or DOT) is approximately 1 cm in width yet can produce sufficient energy to stimulate cortical activity on-demand through the dura. This extreme miniaturization is possible using recently developed magnetoelectric wireless power transfer that allows us to reach power levels required to stimulate the surface of the brain without direct contact to the cortical surface. This externally powered cortical stimulation (XCS) opens the possibility of simple minimally invasive surgical procedures to enable precise, long-lasting, and at-home neuromodulation with tiny implants that never contact the surface of the brain.en_US
dc.embargo.lift2024-12-01en_US
dc.embargo.terms2024-12-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationWoods, Joshua. "Millimeter-sized battery-free epidural cortical stimulators." (2023). Master's thesis, Rice University. https://hdl.handle.net/1911/115393en_US
dc.identifier.urihttps://hdl.handle.net/1911/115393en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectbattery-freeen_US
dc.subjectneuromodulationen_US
dc.subjectcortical stimulationen_US
dc.titleMillimeter-sized battery-free epidural cortical stimulatorsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical and Computer Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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