A model of the rate dependence of the atrial action potential in rabbit

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dc.contributor.advisorClark, John W., Jr.en_US
dc.creatorLindblad, Douglas S.en_US
dc.date.accessioned2009-06-04T00:32:59Zen_US
dc.date.available2009-06-04T00:32:59Zen_US
dc.date.issued1994en_US
dc.description.abstractWe have developed a mathematical model of the rabbit atrial myocyte in order to investigate the ionic bases of rate dependent changes in action potential (AP) wave-shape. Postulated mediators of such changes include rate dependencies of ionic currents (incomplete reactivation) and ionic concentration gradients. The model utilizes biophysical data to quantify the specific morphology and electrophysiology of the rabbit atrial cell. Ionic current descriptions incorporate whole-cell voltage-clamp data from enzymatically isolated rabbit cardiomyocytes, and account for the reactivation timecourse of the largest ionic currents. Our model can simulate both the whole-cell voltage-clamp data upon which it is based and the steady-state AP wave-shapes observed over a range of stimulus rates. It also predicts the intracellular $\lbrack Ca\sp{2+}\rbrack\sb{i}$-transient that accompanies the AP, the "premature stimulus" response, and the effect of rapid stimulation on the AP. These responses provide insight into the electrophysiological mediators of atrial refractoriness and arrhythmia.en_US
dc.format.extent150 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS E.E. 1994 LINDBLADen_US
dc.identifier.citationLindblad, Douglas S.. "A model of the rate dependence of the atrial action potential in rabbit." (1994) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/13859">https://hdl.handle.net/1911/13859</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/13859en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectPhysiologyen_US
dc.subjectBiomedical engineeringen_US
dc.subjectBiophysicsen_US
dc.titleA model of the rate dependence of the atrial action potential in rabbiten_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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