A model of the rate dependence of the atrial action potential in rabbit

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dc.contributor.advisorClark, John W., Jr.
dc.creatorLindblad, Douglas S.
dc.date.accessioned2009-06-04T00:32:59Z
dc.date.available2009-06-04T00:32:59Z
dc.date.issued1994
dc.description.abstractWe have developed a mathematical model of the rabbit atrial myocyte in order to investigate the ionic bases of rate dependent changes in action potential (AP) wave-shape. Postulated mediators of such changes include rate dependencies of ionic currents (incomplete reactivation) and ionic concentration gradients. The model utilizes biophysical data to quantify the specific morphology and electrophysiology of the rabbit atrial cell. Ionic current descriptions incorporate whole-cell voltage-clamp data from enzymatically isolated rabbit cardiomyocytes, and account for the reactivation timecourse of the largest ionic currents. Our model can simulate both the whole-cell voltage-clamp data upon which it is based and the steady-state AP wave-shapes observed over a range of stimulus rates. It also predicts the intracellular $\lbrack Ca\sp{2+}\rbrack\sb{i}$-transient that accompanies the AP, the "premature stimulus" response, and the effect of rapid stimulation on the AP. These responses provide insight into the electrophysiological mediators of atrial refractoriness and arrhythmia.
dc.format.extent150 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS E.E. 1994 LINDBLAD
dc.identifier.citationLindblad, Douglas S.. "A model of the rate dependence of the atrial action potential in rabbit." (1994) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/13859">https://hdl.handle.net/1911/13859</a>.
dc.identifier.urihttps://hdl.handle.net/1911/13859
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectPhysiology
dc.subjectBiomedical engineering
dc.subjectBiophysics
dc.titleA model of the rate dependence of the atrial action potential in rabbit
dc.typeThesis
dc.type.materialText
thesis.degree.departmentElectrical Engineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
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