Coronary Artery Computational Flow Analysis with Isogeometric Discretization

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dc.contributor.advisorTezduyar, Tayfun Een_US
dc.creatorYu, Yuxuanen_US
dc.date.accessioned2019-05-16T19:58:45Zen_US
dc.date.available2019-05-16T19:58:45Zen_US
dc.date.created2017-08en_US
dc.date.issued2017-07-26en_US
dc.date.submittedAugust 2017en_US
dc.date.updated2019-05-16T19:58:45Zen_US
dc.description.abstractPatient-specific computational flow analysis of the coronary artery can provide valuable information that the doctor can use in making treatment decisions. Reliable analysis requires addressing a number of computational challenges. The challenges include the dynamic nature of the analysis due to the arterial motion, accurately representing the flow near the arterial wall, and nonlinearity of the arterial-wall material. Our core technology in addressing these challenges is the Space-Time Variational Multiscale method, which, because of its moving-mesh nature, maintains the high-resolution representation of the boundary layers near the wall as the artery moves. The isogeometric discretization increases the fluid mechanics accuracy even more by providing smoother representation of the wall geometry and more accuracy in the flow solution. The image-based geometries do not come from a zero-stress state (ZSS) of the arterial wall, which we need in nonlinear structural mechanics, and we handle that with a special method for computing the element-based ZSS. In our comparative studies, we compute the unsteady flow field i) for a given, fixed shape of the artery, ii) for wall deformation driven by the physiological blood pressure, iii) for wall motion fully prescribed based on the time-dependent medical images, and iv) for wall deformation driven by the physiological blood pressure in combination with the motion of a thin strip along the arterial surface coming from the medical images.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationYu, Yuxuan. "Coronary Artery Computational Flow Analysis with Isogeometric Discretization." (2017) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/105460">https://hdl.handle.net/1911/105460</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/105460en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectEstimated element-based zero-stress stateen_US
dc.subjectCoronary artery flowen_US
dc.subjectTime-dependent anatomical modelen_US
dc.subjectIsogeometric discretizationen_US
dc.subjectSpace–Time VMS methoden_US
dc.subjecten_US
dc.titleCoronary Artery Computational Flow Analysis with Isogeometric Discretizationen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentMechanical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.majorAdvanced Flow Simulation and Modelingen_US
thesis.degree.nameMaster of Scienceen_US
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