Rodent deep brain stimulation hardware and mechanisms

dc.contributor.advisorKemere, Caleben_US
dc.creatorLewis, Ericen_US
dc.date.accessioned2019-05-17T15:06:22Zen_US
dc.date.available2019-05-17T15:06:22Zen_US
dc.date.created2018-08en_US
dc.date.issued2018-08-10en_US
dc.date.submittedAugust 2018en_US
dc.date.updated2019-05-17T15:06:22Zen_US
dc.description.abstractThis thesis developed an inexpensive, wirelessly programmable deep brain stimulator to evaluate novel stimulation patterns in rodent Parkinson’s Disease (PD). Current deep brain stimulators for Parkinson’s patients only benefit two-thirds of people implanted. The need to develop more effective treatments for Parkinson’s inspired genetic disease models to study the mechanisms of the disease. Stimulators for rodent models exist but can be improved. The head-mounted stimulator in this thesis builds on prior designs through Near Field Communication (NFC) to program stimulator settings. Additionally, the stimulator can provide uniformly distributed offsets to pulse times called ”jitter.” The stimulator efficacy was evaluated in 6- Hydroxydopamine (OHDA) rats through methamphetamine induced rotation studies. High Frequency Stimulation (HFS) corrected ipsilateral rotation and induced transient contralateral rotation in agreement with prior behavioral studies. With this open source hardware, labs can implement novel deep brain stimulation patterns chronically in new disease models to improve stimulation performance for Parkinson’s.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationLewis, Eric. "Rodent deep brain stimulation hardware and mechanisms." (2018) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/105744">https://hdl.handle.net/1911/105744</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/105744en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectMSP430en_US
dc.subjectrodenten_US
dc.subject6-OHDAen_US
dc.subjectirregularen_US
dc.subjectstimulationen_US
dc.subjectNFCen_US
dc.titleRodent deep brain stimulation hardware and mechanismsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical and Computer Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
LEWIS-DOCUMENT-2018.pdf
Size:
73.28 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.84 KB
Format:
Plain Text
Description:
No Thumbnail Available
Name:
LICENSE.txt
Size:
2.6 KB
Format:
Plain Text
Description: