In this paper, we propose a novel low complexity minimum mean square error (MMSE) interference cancellation (IC) to minimize the residual inter-symbol and inter-antenna interference in LTE/LTE-Advanced uplink. In the LTE/LTE-Advanced base station, frequency domain equalizers (FDEs) are adopted to achieve good performance. However, in multi-tap channels, the residual interference of FDE still degrades the performance. Conventional IC schemes can minimize this interference, but have high complexity and large feedback latency. These result in low throughput and require a large amount of resource in software defined radio (SDR) implementation. We show that our scheme can bring up to 8 dB gains in different channels, but only adds up to 7.2% complexity to the receiver. Compared to conventional IC, our scheme has fewer multiplications, less data to store, and shorter feedback latency.