Fluorinated Graphene Oxide: structure, morphology and its potential use in biological applications

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dc.contributor.advisorAjayan, Pulickel M.en_US
dc.contributor.committeeMemberVajtai, Roberten_US
dc.contributor.committeeMemberGrande-Allen, K. Janeen_US
dc.contributor.committeeMemberWest, Jennifer L.en_US
dc.contributor.committeeMemberMani, Sendurai Aen_US
dc.creatorRomero Aburto, Rebecaen_US
dc.date.accessioned2014-10-10T20:43:53Zen_US
dc.date.available2014-11-01T05:10:03Zen_US
dc.date.created2014-05en_US
dc.date.issued2014-04-25en_US
dc.date.submittedMay 2014en_US
dc.date.updated2014-10-10T20:43:53Zen_US
dc.description.abstractThe main objective of this work is to report a novel carbon nanomaterial that can serve as a theranostic agent. This thesis will elaborate on the structure, chemical functionalization, morphology, size distribution and biological applications of this material. Then, this thesis will discuss the limitations of this material and propose an optimization for these drawbacks. Fluorinated Graphene Oxide (FGO) is reported for the first time as a potential multimodal contrast agent, drug carrier as well as a photothermal therapy. FGO is a sheet like material with oxygen and fluorine functional groups present in the structure, a complete characterization of the material is offered in the following pages. Non-cytotoxic FGO exhibited paramagnetic behavior and was able to confer Magnetic Resonance Imaging (MRI) contrast. When irradiated with a Near Infra Red (NIR)-laser, FGO was able to exhibit photoacoustic contrast and serve as a photothermal therapy being able to ablate cancer cells in vitro. The limitation of FGO is its size (500-1000nm). Therefore, density gradient ultracentrifugation was successfully used to size select this material, resulting in a fraction containing sheet sizes around 200nm. Additionally, Fluorinated Graphene Oxide Nanoribbons (FGONRs) will be synthesized, characterized and evaluated as a possible optimization of FGO. However, after the systematic FGONRs, did not result in an optimization with respect to FGO. The ribbons exhibit a diamagnetic behavior and their length is comparable to the length of FGO.en_US
dc.embargo.terms2014-11-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationRomero Aburto, Rebeca. "Fluorinated Graphene Oxide: structure, morphology and its potential use in biological applications." (2014) Diss., Rice University. <a href="https://hdl.handle.net/1911/77513">https://hdl.handle.net/1911/77513</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/77513en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectFunctionalized grapheneen_US
dc.subjectTheranostic nanomaterialsen_US
dc.subjectMagnetic resonance imaging (MRI) contrast agentsen_US
dc.subjectPhotoacoustic imagingen_US
dc.subjectPhotothermal therapyen_US
dc.subjectHyperthermiaen_US
dc.titleFluorinated Graphene Oxide: structure, morphology and its potential use in biological applicationsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentMechanical Engineering and Materials Scienceen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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