Nanoshells in vivo imaging using two-photon excitation microscopy

Simple item page
dc.contributor.advisorDickinson, Mary E.
dc.creatorGao, Liang
dc.date.accessioned2011-07-25T02:07:25Z
dc.date.available2011-07-25T02:07:25Z
dc.date.issued2010
dc.description.abstractThis thesis describes the development and optical characterization of near infrared (NIR) gold nanoshells for the use as luminescent contrast agents for applications in small animal blood vessel imaging. Two types of gold-silica nanoshells excitable by NIR lasers are investigated: Type 1 nanoshells can be excited with a sub-mum NW laser, whereas Type 2 nanoshells can be excited with a NW laser in the micrometer range. Using NIR microscopy as an imaging platform, ex vivo and in vivo experiments are conducted to determine the efficacy of these nanoshells as suitable contrast agents. Specifically, individual particles of Type 1 nanoshells are successfully imaged and shown to provide bright optical contrast for blood vessel imaging both ex vivo and in vivo, while the Type 2 nanoshells are clearly imaged within the blood vessels ex vivo. These positive results suggest a promising possibility of developing a new class of contrast agents for deep tissue imaging and improving the imaging depth of NIR imaging techniques.
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS BIOENG. 2010 GAO
dc.identifier.citationGao, Liang. "Nanoshells in vivo imaging using two-photon excitation microscopy." (2010) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/62198">https://hdl.handle.net/1911/62198</a>.
dc.identifier.urihttps://hdl.handle.net/1911/62198
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectNanotechnology
dc.subjectBiochemistry
dc.subjectPhysiology
dc.subjectBiophysics
dc.titleNanoshells in vivo imaging using two-photon excitation microscopy
dc.typeThesis
dc.type.materialText
thesis.degree.departmentBioengineering
thesis.degree.disciplineEngineering
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1486034.PDF
Size:
1.82 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Electronic Theses and Dissertations