Accurate noninvasive monitoring of fetal tissue oxygenation level

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dc.contributor.advisorRobinson, Jacob Ten_US
dc.creatorGuo, Zijingen_US
dc.date.accessioned2024-05-20T20:20:12Zen_US
dc.date.created2024-05en_US
dc.date.issued2024-04-01en_US
dc.date.submittedMay 2024en_US
dc.date.updated2024-05-20T20:20:12Zen_US
dc.descriptionEMBARGO NOTE: This item is embargoed until 2024-11-01en_US
dc.description.abstractFetal blood oxygenation level serves as a critical indicator of fetal health throughout pregnancy and labor. However, existing clinical devices predominantly employ invasive techniques, posing risks to both the fetus and the mother. To address this concern, we present a noninvasive method for precise fetal oxygenation level monitoring using time-of-flight near-Infrared Spectroscopy (ToF-NIRS). Our method is the first to achieve accurate, multichannel signal separation from two distinct layers. We conducted Monte Carlo simulations and experiments on a fiber-based ToF-NIRS prototype. Our prototype system achieves <3% estimation error in a two-layer tissue phantom. Additionally, we perform in-vivo experiments to show that our system is able to detect reduced tissue oxygenation index (TOI) levels in a human arm, through a human tissue phantom, and can perform transabdominal fetal monitoring in living sheep. Our approach is a step towards reliable and noninvasive fetal oxygenation level monitoring in clinical settings.en_US
dc.embargo.lift2024-11-01en_US
dc.embargo.terms2024-11-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationGuo, Zijing. Accurate noninvasive monitoring of fetal tissue oxygenation level. (2024). Masters thesis, Rice University. https://hdl.handle.net/1911/115917en_US
dc.identifier.urihttps://hdl.handle.net/1911/115917en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectTime-domain NIRSen_US
dc.subjectTissue oxygenation level monitoringen_US
dc.titleAccurate noninvasive monitoring of fetal tissue oxygenation levelen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical and Computer Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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