Synthesis of optically pure mitomycin C: A new route to FR900482

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dc.contributor.advisorFukuyama, Tohru
dc.creatorLinsell, Martin Sheringham
dc.date.accessioned2009-06-04T00:10:15Z
dc.date.available2009-06-04T00:10:15Z
dc.date.issued1994
dc.description.abstractOptically pure mitomycin C was synthesized in 28 steps and 5% overall yield from 2,6-dimethoxytoluene. The route followed was a variation upon previous work in our laboratories and the asymmetry was achieved by the resolution of racemic mitomycin A, an advanced intermediate. Our efforts at finding a new route to an intermediate in the synthesis of FR900482, are also described here. The key step was the cyclization of an epoxy-acetamide under basic conditions to form an eight-membered lactam.
dc.format.extent140 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS CHEM. 1994 LINSELL
dc.identifier.citationLinsell, Martin Sheringham. "Synthesis of optically pure mitomycin C: A new route to FR900482." (1994) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/13860">https://hdl.handle.net/1911/13860</a>.
dc.identifier.urihttps://hdl.handle.net/1911/13860
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectOrganic chemistry
dc.titleSynthesis of optically pure mitomycin C: A new route to FR900482
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemistry
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelMasters
thesis.degree.nameMaster of Arts
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