Biomedical studies of single -walled carbon nanotubes using near-infrared fluorescence

Simple item page
dc.contributor.advisorWeisman, R. Bruceen_US
dc.creatorCherukuri, Paulen_US
dc.date.accessioned2018-12-03T18:32:08Zen_US
dc.date.available2018-12-03T18:32:08Zen_US
dc.date.issued2007en_US
dc.description.abstractExperimental studies will be described aimed at providing a scientific foundation for the use of single-walled carbon nanotubes (SWNTs) in biomedical applications. SWNTs have been found to be a unique class of nanoscale near-infrared (NIR) fluorescence contrast agents that also exhibit novel therapeutic capabilities. In our first study, we found that cultured macrophage cells readily engulf individual nanotubes. The rate of cellular uptake of SWNTs was measured by monitoring their characteristic NIR emissions. Furthermore, we also found that the NIR emissions of individual SWNTs are persistent in both the extracellular and intracellular environment of macrophage cells. Next, we extended our study from simple in vitro systems to the more complex in vivo mammalian animal model. By quantitatively tracking individual SWNTs, we have determined the rabbit's pharmacokinetic SWNT profile without the aid of additional fluorophores or radiolabels. As a final therapeutic application, we have developed SWNTs as novel pharmaceutical agents that efficiently carry siRNA molecules into cancer cells in order to induce targeted apoptosis of specific tumors.en_US
dc.format.extent132 ppen_US
dc.identifier.callnoTHESIS CHEM. 2008 CHERUKURIen_US
dc.identifier.citationCherukuri, Paul. "Biomedical studies of single -walled carbon nanotubes using near-infrared fluorescence." (2007) Diss., Rice University. <a href="https://hdl.handle.net/1911/103643">https://hdl.handle.net/1911/103643</a>.en_US
dc.identifier.digital304801046en_US
dc.identifier.urihttps://hdl.handle.net/1911/103643en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectPharmacy sciencesen_US
dc.subjectPhysical chemistryen_US
dc.subjectCondensed matter physicsen_US
dc.subjectPure sciencesen_US
dc.subjectApoptosisen_US
dc.subjectNanotubes Single-walled carbon nanotubesen_US
dc.subjectsiRNAen_US
dc.titleBiomedical studies of single -walled carbon nanotubes using near-infrared fluorescenceen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
304801046.pdf
Size:
3.92 MB
Format:
Adobe Portable Document Format
Download
Collections
Rice University Theses and Dissertations