Synthetic studies of luzopeptins

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dc.contributor.advisorCiufolini, Marco A.en_US
dc.creatorXi, Ningen_US
dc.date.accessioned2009-06-04T08:32:43Zen_US
dc.date.available2009-06-04T08:32:43Zen_US
dc.date.issued1997en_US
dc.description.abstractLuzopeptins are a series of cyclic depsipeptides which possesses potent antitumor and antiviral activities. There is no total synthesis of Luzopeptins has been achieved. In our own effort to synthesize the luzopeptins, we developed a concise and practical route to PCA, 86, and an efficient protocol to synthesize the mono-BOC, 181. A novel serinyl chloride was devised in conjunction with the formation of PCA-serine dipeptide derivatives, 164. All these methodologies were successfully applied to the synthesis of monomeric derivative of luzopeptin E$\sb2,$ 288.* ftn*Please refer to the dissertation for diagram.en_US
dc.format.extent201 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS CHEM. 1997 XIen_US
dc.identifier.citationXi, Ning. "Synthetic studies of luzopeptins." (1997) Diss., Rice University. <a href="https://hdl.handle.net/1911/19235">https://hdl.handle.net/1911/19235</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/19235en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectOrganic chemistryen_US
dc.titleSynthetic studies of luzopeptinsen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentChemistryen_US
thesis.degree.disciplineNatural Sciencesen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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