Rice Coronavirus Research
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Works related to coronaviruses that are authored by members of the Rice community.
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Browsing Rice Coronavirus Research by Subject "COVID-19"
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Item Confident futures: Community-based organizations as first responders and agents of change in the face of the Covid-19 pandemic(Elsevier, 2022) Roels, Nastasja Ilonka; Estrella, Amarilys; Maldonado-Salcedo, Melissa; Rapp, Rayna; Hansen, Helena; Hardon, AnitaThis comparative study of community organizations serving marginalized youth in New York City and Amsterdam utilized a novel ethnographic approach called reverse engineering to identify techniques for social change that are active in each organization, adaptable and translatable to other contexts. It found that youth-serving organizations led flexible responses to the crisis of COVID-19 as it affected those marginalized by race, immigrant status, housing instability, religion and gender. The organizations employed techniques that they had previously developed to cultivate youth well-being – among them connectivity, safe space, and creativity – to mount tailored responses to COVID-19 related crises. In New York City, these groups addressed crises of material survival resources (personal protective equipment, food, housing) whereas in Amsterdam, youth-serving organizations focused on social connections and emotional well-being as the government met more of participants’ material needs.Item Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses(2020) Amirian, E. Susan; Levy, Julie K.; Texas Policy Lab; ElsevierRecent international epidemics of coronavirus-associated illnesses underscore the urgent medical and public health need for vaccine development and regulatory body approved therapies. In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human life. Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. Currently available evidence about the antiviral effects of remdesivir against coronaviruses is primarily based on in vitro and in vivo studies (including some on a chemically related compound, GS-441524™), which have demonstrated largely favorable findings. As the pandemic progresses, information from human compassionate use cases will continue to accumulate before the clinical trials are concluded. It is imperative for public health practitioners and the One Health community to stay up to date on the most promising potential therapeutic options that are under investigation. Thus, the purpose of this review is to synthesize the knowledge to date about remdesivir as a therapeutic option for coronaviruses, with a special focus on information relevant to the One Health community.Item Dying in the Face of the COVID-19 Pandemic: Contextual Considerations and Clinical Recommendations(American Psychological Association, 2020) LeRoy, Angie S.; Robles, Barbara; Kilpela, Lisa S.; Garcini, Luz M.Dying is a natural part of life; however, death is often a fearful, frightening event. Dying in the midst of the COVID-19 pandemic presents challenges that magnify normative fears and may interfere with a healthy grieving process. To maintain a resilient spirit among those who are at risk of losing a loved one or who have lost a family member to COVID-19, it is important that they be provided with the necessary contextually and culturally appropriate skills and resources to facilitate healing in the face of hardship and uncertainty.Item Filipinx Care, Social Proximity, and Social Distance(Duke University Press, 2021) Marte-Wood, Alden SajorItem Potential fecal transmission of SARS-CoV-2: Current evidence and implications for public health(Elsevier, 2020) Amirian, E. SusanCoronavirus disease 2019 (COVID-19) emerged in Hubei Province, China in December 2019 and has since become a global pandemic, with hundreds of thousands of cases and over 165 countries affected. Primary routes of transmission of the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are through respiratory droplets and close person-to-person contact. While information about other potential modes of transmission are relatively sparse, evidence supporting the possibility of a fecally mediated mode of transmission has been accumulating. Here, current knowledge on the potential for fecal transmission is briefly reviewed and the possible implications are discussed from a public health perspective.Item Role of miR-2392 in driving SARS-CoV-2 infection(Elsevier, 2021) McDonald, J. Tyson; Enguita, Francisco J.; Taylor, Deanne; Griffin, Robert J.; Priebe, Waldemar; Emmett, Mark R.; Sajadi, Mohammad M.; Harris, Anthony D.; Clement, Jean; Dybas, Joseph M.; Aykin-Burns, Nukhet; Guarnieri, Joseph W.; Singh, Larry N.; Grabham, Peter; Baylin, Stephen B.; Yousey, Aliza; Pearson, Andrea N.; Corry, Peter M.; Saravia-Butler, Amanda; Aunins, Thomas R.; Sharma, Sadhana; Nagpal, Prashant; Meydan, Cem; Foox, Jonathan; Mozsary, Christopher; Cerqueira, Bianca; Zaksas, Viktorija; Singh, Urminder; Wurtele, Eve Syrkin; Costes, Sylvain V.; Davanzo, Gustavo Gastão; Galeano, Diego; Paccanaro, Alberto; Meinig, Suzanne L.; Hagan, Robert S.; Bowman, Natalie M.; Wallet, Shannon M.; Maile, Robert; Wolfgang, Matthew C.; Hagan, Robert S.; Mock, Jason R.; Bowman, Natalie M.; Torres-Castillo, Jose L.; Love, Miriya K.; Meinig, Suzanne L.; Lovell, Will; Rice, Colleen; Mitchem, Olivia; Burgess, Dominique; Suggs, Jessica; Jacobs, Jordan; Wolfgang, Matthew C.; Altinok, Selin; Sapoval, Nicolae; Treangen, Todd J.; Moraes-Vieira, Pedro M.; Vanderburg, Charles; Wallace, Douglas C.; Schisler, Jonathan C.; Mason, Christopher E.; Chatterjee, Anushree; Meller, Robert; Beheshti, AfshinMicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we design a miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters, and may potentially inhibit a COVID-19 disease state in humans.Item The Effect of the Crowd on Home Bias: Evidence from NBA Games During the COVID-19 Pandemic(Sage, 2022) Gong, HuaThe present study examines a specific type of referee biases, home bias, and analyzes how the presence of fans affects home bias by using NBA games played in empty arenas during the COVID-19 pandemic in the 2020–2021 season and matches played before the pandemic from 2017 to 2020. This research also uses a unique data set from NBA Last Two Minute Reports to assess referees’ performance at the play level. The findings show crowd support does not cause referees to treat home and away teams differently in crucial situations during the NBA regular season, contrary to the results in most prior studies.