Wiess School of Natural Sciences
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Browsing Wiess School of Natural Sciences by Subject "3D culture"
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Item Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures(Wiley, 2015) Engel, Brian J.; Constantinou, Pamela E.; Sablatura, Lindsey K.; Doty, Nathaniel J.; Carson, Daniel D.; Farach-Carson, Mary C.; Harrington, Daniel Anton; Zarembinski, Thomas I.Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture.