Browsing by Author "Zhang, David"

Now showing 1 - 3 of 3
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    Method, apparatus, and computer-readable medium for predicting a hybridization rate constant of a first sequence
    (2022-10-18) Zhang, Xuemeng; Fang, Zheng; Wu, Ruojia; Duan, Wei; Zhang, David; Rice University; William Marsh Rice University; United States Patent and Trademark Office
    Embodiments of methods, systems, and tangible non-transitory computer readable medium having instructions are presented. A method includes calculating a plurality of feature values for a number of bioinformatic features of the desired hybridization reaction; and calculating distances between the plurality of feature values and corresponding database rate constant values stored in a database, the database comprising a plurality of hybridization reactions having known rate constants. The method additionally includes calculating a weighted average of a logarithm of the database rate constant values, with larger weights assigned to value instances having values lower in distance to the plurality of feature values of the desired hybridization reaction; and providing the weighted average as a predicted logarithm of the rate constant of the desired hybridization reaction.
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    Molecular hybridization probes for complex sequence capture and analysis
    (2022-11-22) Zhang, David; Wang, Juexiao; Yan, Yan; Rice University; William Marsh Rice University; United States Patent and Trademark Office
    This present disclosure describes hybridization probes modularly constructed from several oligonucleotides with a pattern of designed complementary interactions, allowing the probes to sequence-specifically capture or analyze nucleic acid target sequences that are long and/or complex.
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    Stoichiometric nucleic acid purification using randomer capture probe libraries
    (2022-08-16) Zhang, David; Pinto, Alessandro; Rice University; William Marsh Rice University; United States Patent and Trademark Office
    This disclosure describes a method of purifying several full-length oligonucleotide targets from corresponding synthesis truncation products, in a way that ensures roughly stoichiometric equality among the targets.