Browsing by Author "Yaseen, Mohammad Abbas"

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    Charge-assembled capsules for phototherapy
    (2012-12-25) Yu, Jie; Wong, Michael S.; Anvari, Bahman; Yaseen, Mohammad Abbas; Rice University; United States Patent and Trademark Office
    Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.
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    Optical characterization and in vivo assessment of charge-assembled capsules containing indocyanine green for laser-mediated diagnosis and therapy
    (2008) Yaseen, Mohammad Abbas; Anvari, Bahman
    We have developed a carrier system to encapsulate Indocyanine Green (ICG) to overcome its limitations for laser-mediated medical applications. Charge-assembled capsules with controllable size and adjustable coatings efficiently encapsulate ICG and effectively stabilize its optical properties. When encapsulated, ICG retains its pronounced light absorption and fluorescence properties in the near infrared spectral range. The capsules' in vivo circulation kinetics and biodistribution can be adjusted by coating the surface with various polymers or nanoparticles. The stability enhancement of ICG's optical properties by encapsulation within our capsule system was investigated using absorbance spectroscopy. The ability of capsules containing ICG to induce photothermolysis was demonstrated in an ex vivo tumorous tissue model. Biodistribution of capsules with different coating material and of different sizes was evaluated in a healthy mouse model. And the circulation kinetics and imaging quality of capsules with different coatings was assessed in mice using in vivo fluorescence imaging. Capsules containing ICG show promise for a variety of laser-mediated medical applications including phothothermal treatment of tumors and vascular lesions as well as fluorescence-based pulmonary imaging.