Browsing by Author "Wang, Ying"

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    Insights on Foam Transport from a Texture-Implicit Local-Equilibrium Model with an Improved Parameter Estimation Algorithm
    (American Chemical Society, 2016) Zeng, Yongchao; Muthuswamy, Aarthi; Ma, Kun; Wang, Le; Farajzadeh, Rouhi; Puerto, Maura; Vincent-Bonnieu, Sebastien; Akbar Eftekhari, Ali; Wang, Ying; Da, Chang; Joyce, Jeffrey C.; Biswal, Sibani L.; Hirasaki, George J.
    We present an insightful discussion on the implications of foam transport inside porous media based on an improved algorithm for the estimation of model parameters. A widely used texture-implicit local-equilibrium foam model, STARS, is used to describe the reduction of gas mobility in the state of foam with respect to free gas. Both the dry-out effect and shear-dependent rheology are considered in foam simulations. We estimate the limiting capillary pressure Pc* from fmdryvalues in the STARS model to characterize foam film stability in a dynamic flowing system. We find that Pc* is a good indicator of foam strength in porous media and varies with different gas types. We also calculate Pc* for different foaming surfactants and find that foam stability is correlated with the Gibbs surface excess concentration. We compare our improved parameter estimation algorithm with others reported in literature. The robustness of the algorithm is validated for various foam systems.
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    Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer
    (Cell Press, 2020) Yang, Guoliang; Bondaruk, Jolanta; Cogdell, David; Wang, Ziqiao; Lee, Sangkyou; Lee, June Goo; Zhang, Shizhen; Choi, Woonyoung; Wang, Yan; Liang, Yu; Wang, Gang; Wang, Ying; Yao, Hui; Dadhania, Vipulkumar; Gao, Jianjun; Logothetis, Christopher; Siefker-Radtke, Arlene; Kamat, Ashish; Dinney, Colin; Theodorescu, Dan; Kimmel, Marek; Wei, Peng; Guo, Charles C.; Weinstein, John N.; McConkey, David J.; Czerniak, Bogdan
    We report a comprehensive molecular analysis of 34 cases of small cell carcinoma (SCC) and 84 cases of conventional urothelial carcinoma (UC), with The Cancer Genome Atlas cohort of 408 conventional UC bladder cancers used as the reference. SCCs showed mutational landscapes characterized by nearly uniform inactivation of TP53 and were dominated by Sanger mutation signature 3 associated with loss of BRCA1/2 function. SCCs were characterized by downregulation of luminal and basal markers and were referred to as double-negative. Transcriptome analyses indicated that SCCs displayed lineage plasticity driven by a urothelial-to-neural phenotypic switch with a dysregulated epithelial-to-mesenchymal transition network. SCCs were depleted of immune cells, and expressed high levels of the immune checkpoint receptor, adenosine receptor A2A (ADORA2A), which is a potent inhibitor of immune infiltration. Our observations have important implications for the prognostication and development of more effective therapies for this lethal bladder cancer variant.