Browsing by Author "Wang, Shuo"

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    A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep
    (Oxford University Press, 2018) Wang, Shuo; Zhao, Zhijun; Yang, Yongdong; Mikos, Antonios G.; Qiu, Zhiye; Song, Tianxi; Cui, Fuzhai; Wang, Xiumei; Zhang, Chunyang
    Large-sized cranial bone defect repair presents a great challenge in the clinic. The ideal cranioplasty materials to realize the functional and cosmetic recovery of the defect must have sufficient mechanical support, excellent biocompatibility, good osseointegration and biodegradability as well. In this study, a high-strength mineralized collagen (MC) bone scaffold was developed with biomimetic composition, microstructure and mechanical properties for the repair of sheep large-sized cranial bone defects in comparison with two traditional cranioplasty materials, polymethyl methacrylate and titanium mesh. The compact MC scaffold showed no distinct pore structure and therefore possessed good mechanical properties. The strength and elastic modulus of the scaffold were much higher than those of natural cancellous bone and slightly lower than those of natural compact bone. In vitro cytocompatibility evaluation revealed that the human bone marrow mesenchymal stem cells (hBMSC) had good viability, attachment and proliferation on the compact MC scaffold indicating its excellent biocompatibility. An adult sheep cranial bone defect model was constructed to evaluate the performances of these cranioplasty materials in repairing the cranial bone defects. The results were investigated by gross observation, computed tomography scanning as well as histological assessments. The in vivo evaluations indicated that compact MC scaffold showed notable osteoconductivity and osseointegration with surrounding cranial bone tissues by promoting bone regeneration. Our results suggested that the compact MC scaffold has a promising potential for large-sized cranial bone defect repair.
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    Enabling the wild Be[ij]ing: Try-out for the future of hyper-density
    (2006) Wang, Shuo; Oliver, Douglas
    EWB is a direct attempt to deal with numerous uncontrolled urban emergences in Beijing; instead of the current stratifying process, it offers strategies for intensifying the dynamic density through enabling the massive subversive forces. In turn, EWB exposes the city's future of unprecedented three-dimensional congestion---a hyper-dense city. EWB respond to the all-encompassing wildness with an approach that merges two opposing concepts of urbanity into one: the top-down plan that treats developments as lockdown enclaves; the unregulated activities that flood the urban ground. It propagates a new urban process by using the vast developments as a framework to proliferate street commerce---instead of being parasitical, unregulated activities can weave into the rigid structure of existing residential blocks and disturb it like a virus infection. Once they reach the critical masses, the city will reinvent itself as an uninterrupted hyper-dense urban landscape capable of accommodating all manners of street life.