Browsing by Author "Wang, Jennifer"

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    Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis
    (eLife, 2021) Onur, Tarik Seref; Laitman, Andrew; Zhao, He; Keyho, Ryan; Kim, Hyemin; Wang, Jennifer; Mair, Megan; Wang, Huilan; Li, Lifang; Perez, Alma; de Haro, Maria; Wan, Ying-Wooi; Allen, Genevera; Lu, Boxun; Al-Ramahi, Ismael; Liu, Zhandong; Botas, Juan
    Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington's disease (HD), we profiled the gene expression alterations of Drosophila expressing human mutant Huntingtin (mHTT) in either glia or neurons and compared these changes to what is observed in HD human and HD mice striata. A large portion of conserved genes are concordantly dysregulated across the three species; we tested these genes in a high-throughput behavioral assay and found that downregulation of genes involved in synapse assembly mitigated pathogenesis and behavioral deficits. To our surprise, reducing dNRXN3 function in glia was sufficient to improve the phenotype of flies expressing mHTT in neurons, suggesting that mHTT's toxic effects in glia ramify throughout the brain. This supports a model in which dampening synaptic function is protective because it attenuates the excitotoxicity that characterizes HD.
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    Literary Landscapes: A Future for Post-Frontier Regionalism in Literature of the American West
    (Rice University, 2020) Wang, Jennifer
    Landscape portrayals—literary, visual, or otherwise—serve as recognizable features at the core of American Western iconography and aesthetics. Renderings of landscape point to an implicit gaze appraising the land—a gaze which often communicates its idealization, condemnation, or contemplation of the American West through physical and metaphorical description. Traditional western landscape portrayals may evoke images of breathtaking wildness, boundless freedom, and infinite potential—a sublime landscape that appeals to settler colonial gazes and fantasies. Through comparative analysis of three texts—The Way West by A. B. Guthrie, Jr. (1949), All the Pretty Horses by Cormac McCarthy (1992), and Ceremony by Leslie Marmon Silko (1977)—this essay examines textual treatment of the land to explore the legacy and future of the American West. Additional literary, historical, and theoretical concepts such as Frontier Theory, the Kantian Sublime, and feminist regionalist scholarship are introduced to explicate the shifting symbolic significance of the American West throughout history, the anthropocentrism underlying both American exceptionalism and settler coloniality, and the avenues of healing that may exist for Indigenous populations on a landscape marked by violence and destruction.