Browsing by Author "Wang, Dan"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Alpha omega bifunctional fatty acids
    (2020-09-15) San, Ka-yiu; Wang, Dan; Rice University; United States Patent and Trademark Office
    The present disclosure describes an engineered microorganism for producing alpha omega bifunctional C6-16 fatty acids from renewable carbon sources.
  • Thumbnail Image
    Item
    KAS-III free FA synthesis
    (2020-12-01) San, Ka-yiu; Zhang, Xian; Wu, Hui; Wang, Dan; Rice University; United States Patent and Trademark Office
    The present disclosure describes a genetically engineered a KASIII-independent fatty acid biosynthetic pathway that makes use of the promiscuous nature of the rest of the FAS enzymes (3-ketoacyl-ACP synthetase, 3-ketoacyl-ACP reductase, 3-hydroxyacyl ACP dehydrase, enoyl-ACP reductase) to bypass the KASIII step by providing a Co-A precursor of two or higher than two carbons (such as the four carbon butyryl-CoA) as the starting molecule. Since many CoA-based starter molecules can be supplied for the fatty acid synthesis, much more diversified products can be obtained with various carbon-chain lengths. As such, this disclosure will serve as a powerful and efficient platform to produce low to medium chain length products carrying many different functional groups.