Browsing by Author "Vourloumis, Dionisios"

Now showing 1 - 2 of 2
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    Desacetoxytubulysin H and analogs thereof
    (2020-10-20) Nicolaou, Kyriacos C.; Vourloumis, Dionisios; Yin, Jun; Erande, Rohan; Mandal, Debashis; Klahn, Phillipp; Rice University; United States Patent and Trademark Office
    "In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. "
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    Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith
    (2022-03-15) Nicolaou, Kyriacos C.; Erande, Rohan Diliprao; Vourloumis, Dionisios; Pulukuri, Kiran Kumar; Rigol, Stephan; Rice University; United States Patent and Trademark Office
    In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.