Browsing by Author "Uzcategui, Nestor L."

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    A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses
    (Springer Nature, 2024) Thimmiraju, Syamala Rani; Adhikari, Rakesh; Redd, JeAnna R.; Villar, Maria Jose; Lee, Jungsoon; Liu, Zhuyun; Chen, Yi-Lin; Sharma, Suman; Kaur, Amandeep; Uzcategui, Nestor L.; Ronca, Shannon E.; Chen, Wen-Hsiang; Kimata, Jason T.; Zhan, Bin; Strych, Ulrich; Bottazzi, Maria Elena; Hotez, Peter J.; Pollet, Jeroen
    The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.