Browsing by Author "Spielmann, H.Peter"

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    Structure and specificity of a permissive bacterial C-prenyltransferase
    (Springer Nature, 2017) Elshahawi, Sherif I.; Cao, Hongnan; Shaaban, Khaled A.; Ponomareva, Larissa V.; Subramanian, Thangaiah; Farman, Mark L.; Spielmann, H.Peter; Phillips, George N.Jr.; Thorson, Jon S.; Singh, Shanteri
    This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.