Browsing by Author "Sheth, Sunil A."

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    A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves
    (Springer Nature, 2022) Chen, Joshua C.; Kan, Peter; Yu, Zhanghao; Alrashdan, Fatima; Garcia, Roberto; Singer, Amanda; Lai, C.S. Edwin; Avants, Ben; Crosby, Scott; Li, Zhongxi; Wang, Boshuo; Felicella, Michelle M.; Robledo, Ariadna; Peterchev, Angel V.; Goetz, Stefan M.; Hartgerink, Jeffrey D.; Sheth, Sunil A.; Yang, Kaiyuan; Robinson, Jacob T.; Applied Physics Program
    Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals’ sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.
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    Miniature battery-free epidural cortical stimulators
    (AAAS, 2024) Woods, Joshua E.; Singer, Amanda L.; Alrashdan, Fatima; Tan, Wendy; Tan, Chunfeng; Sheth, Sunil A.; Sheth, Sameer A.; Robinson, Jacob T.; Applied Physics Program
    Miniaturized neuromodulation systems could improve the safety and reduce the invasiveness of bioelectronic neuromodulation. However, as implantable bioelectronic devices are made smaller, it becomes difficult to store enough power for long-term operation in batteries. Here, we present a battery-free epidural cortical stimulator that is only 9 millimeters in width yet can safely receive enough wireless power using magnetoelectric antennas to deliver 14.5-volt stimulation bursts, which enables it to stimulate cortical activity on-demand through the dura. The device has digitally programmable stimulation output and centimeter-scale alignment tolerances when powered by an external transmitter. We demonstrate that this device has enough power and reliability for real-world operation by showing acute motor cortex activation in human patients and reliable chronic motor cortex activation for 30 days in a porcine model. This platform opens the possibility of simple surgical procedures for precise neuromodulation.